Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL)

About Hydroxymethylglutaryl-CoA lyase, mitochondrial

Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL) is a protein from Homo sapiens identified by UniProt accession P35914, 325 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	Hydroxymethylglutaryl-CoA lyase, mitochondrial
UniProt accession	P35914
Gene	HMGCL
Organism	Homo sapiens
Length	325 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

3-hydroxy-3-methylglutaric aciduria · score 0.84
long chain 3-hydroxyacyl-CoA dehydrogenase deficiency · score 0.52
genetic disorder · score 0.49
Intellectual disability · score 0.37
reticulocyte count · score 0.27
neurodegenerative disease · score 0.21
erythrocyte count · score 0.14
mean corpuscular hemoglobin · score 0.11
red blood cell density measurement · score 0.10
hepatocellular carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35914-F1	alphafold	PREDICTED	91.98	—

Amino-acid sequence (325 residues)

MAAMRKALPR RLVGLASLRA VSTSSMGTLP KRVKIVEVGP RDGLQNEKNI VSTPVKIKLI DMLSEAGLSV IETTSFVSPK WVPQMGDHTE VLKGIQKFPG INYPVLTPNL KGFEAAVAAG AKEVVIFGAA SELFTKKNIN CSIEESFQRF DAILKAAQSA NISVRGYVSC ALGCPYEGKI SPAKVAEVTK KFYSMGCYEI SLGDTIGVGT PGIMKDMLSA VMQEVPLAAL AVHCHDTYGQ ALANTLMALQ MGVSVVDSSV AGLGGCPYAQ GASGNLATED LVYMLEGLGI HTGVNLQKLL EAGNFICQAL NRKTSSKVAQ ATCKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards