26S proteasome regulatory subunit 7 (PSMC2)

About 26S proteasome regulatory subunit 7

26S proteasome regulatory subunit 7 (PSMC2) is a protein from Homo sapiens identified by UniProt accession P35998, 433 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	26S proteasome regulatory subunit 7
UniProt accession	P35998
Gene	PSMC2
Organism	Homo sapiens
Length	433 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
lung adenocarcinoma · score 0.29
endometrial cancer · score 0.29
head and neck squamous cell carcinoma · score 0.29
urinary bladder cancer · score 0.28
squamous cell lung carcinoma · score 0.28
gastric adenocarcinoma · score 0.27
multiple myeloma · score 0.24
hepatocellular carcinoma · score 0.20
neurodegenerative disease · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P35998-F1	alphafold	PREDICTED	80.53	—

Amino-acid sequence (433 residues)

MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC KEQIEKLREV VETPLLHPER FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV IGSELVQKYV GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG RTHIFKIHAR SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR RKIATEKDFL EAVNKVIKSY AKFSATPRYM TYN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards