About Monocarboxylate transporter 8
Monocarboxylate transporter 8 (SLC16A2) is a protein
from Homo sapiens identified by UniProt accession
P36021, 539 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | Monocarboxylate transporter 8 |
|---|
| UniProt accession | P36021 |
|---|
| Gene | SLC16A2 |
|---|
| Organism | Homo sapiens |
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| Length | 539 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (141)
Diseases linked to this target (Open Targets).
- Allan-Herndon-Dudley syndrome · score 0.85
- Spastic paraplegia · score 0.55
- genetic disorder · score 0.53
- neurodegenerative disease · score 0.41
- Intellectual disability · score 0.35
- hereditary spastic paraplegia · score 0.32
- Decreased activity of the pyruvate dehydrogenase complex · score 0.27
- cutaneous melanoma · score 0.22
- hemoglobin A1 measurement · score 0.13
- prostate carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36021-F1 | alphafold | PREDICTED | 79.58 | — |
Amino-acid sequence (539 residues)
MALQSQASEE AKGPWQEADQ EQQEPVGSPE PESEPEPEPE PEPVPVPPPE PQPEPQPLPD PAPLPELEFE SERVHEPEPT PTVETRGTAR GFQPPEGGFG WVVVFAATWC NGSIFGIHNS VGILYSMLLE EEKEKNRQVE FQAAWVGALA MGMIFFCSPI VSIFTDRLGC RITATAGAAV AFIGLHTSSF TSSLSLRYFT YGILFGCGCS FAFQPSLVIL GHYFQRRLGL ANGVVSAGSS IFSMSFPFLI RMLGDKIKLA QTFQVLSTFM FVLMLLSLTY RPLLPSSQDT PSKRGVRTLH QRFLAQLRKY FNMRVFRQRT YRIWAFGIAA AALGYFVPYV HLMKYVEEEF SEIKETWVLL VCIGATSGLG RLVSGHISDS IPGLKKIYLQ VLSFLLLGLM SMMIPLCRDF GGLIVVCLFL GLCDGFFITI MAPIAFELVG PMQASQAIGY LLGMMALPMI AGPPIAGLLR NCFGDYHVAF YFAGVPPIIG AVILFFVPLM HQRMFKKEQR DSSKDKMLAP DPDPNGELLP GSPNPEEPI
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