Chitinase-3-like protein 1 (CHI3L1)

About Chitinase-3-like protein 1

Chitinase-3-like protein 1 (CHI3L1) is a protein from Homo sapiens identified by UniProt accession P36222, 383 residues long. MolForge cross-references it against 0 known binders and 860 disease associations.

Target properties

Protein name	Chitinase-3-like protein 1
UniProt accession	P36222
Gene	CHI3L1
Organism	Homo sapiens
Length	383 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (860)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.38
blood protein measurement · score 0.36
YKL40 measurement · score 0.33
protein measurement · score 0.23
asthma · score 0.20
drug use measurement · score 0.16
chitotriosidase-1 measurement · score 0.12
neoplasm · score 0.12
cancer · score 0.12
inflammatory bowel disease · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P36222-F1	alphafold	PREDICTED	94.70	—

Amino-acid sequence (383 residues)

MGVKASQTGF VVLVLLQCCS AYKLVCYYTS WSQYREGDGS CFPDALDRFL CTHIIYSFAN ISNDHIDTWE WNDVTLYGML NTLKNRNPNL KTLLSVGGWN FGSQRFSKIA SNTQSRRTFI KSVPPFLRTH GFDGLDLAWL YPGRRDKQHF TTLIKEMKAE FIKEAQPGKK QLLLSAALSA GKVTIDSSYD IAKISQHLDF ISIMTYDFHG AWRGTTGHHS PLFRGQEDAS PDRFSNTDYA VGYMLRLGAP ASKLVMGIPT FGRSFTLASS ETGVGAPISG PGIPGRFTKE AGTLAYYEIC DFLRGATVHR ILGQQVPYAT KGNQWVGYDD QESVKSKVQY LKDRQLAGAM VWALDLDDFQ GSFCGQDLRF PLTNAIKDAL AAT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards