About Glutathione hydrolase 5 proenzyme
Glutathione hydrolase 5 proenzyme (GGT5) is a protein
from Homo sapiens identified by UniProt accession
P36269, 586 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Glutathione hydrolase 5 proenzyme |
|---|
| UniProt accession | P36269 |
|---|
| Gene | GGT5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 586 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.46
- eosinophil count · score 0.46
- leukocyte count · score 0.39
- lymphocyte count · score 0.38
- mean corpuscular hemoglobin · score 0.37
- myeloid white cell count · score 0.37
- monocyte percentage of leukocytes · score 0.36
- eosinophil percentage of leukocytes · score 0.34
- mean corpuscular volume · score 0.34
- granulocyte percentage of myeloid white cells · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36269-F1 | alphafold | PREDICTED | 92.09 | — |
Amino-acid sequence (586 residues)
MARGYGATVS LVLLGLGLAL AVIVLAVVLS RHQAPCGPQA FAHAAVAADS KVCSDIGRAI LQQQGSPVDA TIAALVCTSV VNPQSMGLGG GVIFTIYNVT TGKVEVINAR ETVPASHAPS LLDQCAQALP LGTGAQWIGV PGELRGYAEA HRRHGRLPWA QLFQPTIALL RGGHVVAPVL SRFLHNSILR PSLQASTLRQ LFFNGTEPLR PQDPLPWPAL ATTLETVATE GVEVFYTGRL GQMLVEDIAK EGSQLTLQDL AKFQPEVVDA LEVPLGDYTL YSPPPPAGGA ILSFILNVLR GFNFSTESMA RPEGRVNVYH HLVETLKFAK GQRWRLGDPR SHPKLQNASR DLLGETLAQL IRQQIDGRGD HQLSHYSLAE AWGHGTGTSH VSVLGEDGSA VAATSTINTP FGAMVYSPRT GIILNNELLD LCERCPRGSG TTPSPVSGDR VGGAPGRCWP PVPGERSPSS MVPSILINKA QGSKLVIGGA GGELIISAVA QAIMSKLWLG FDLRAAIAAP ILHVNSKGCV EYEPNFSQEV QRGLQDRGQN QTQRPFFLNV VQAVSQEGAC VYAVSDLRKS GEAAGY
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