Gap junction gamma-1 protein (GJC1)

About Gap junction gamma-1 protein

Gap junction gamma-1 protein (GJC1) is a protein from Homo sapiens identified by UniProt accession P36383, 396 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.

Target properties

Protein name	Gap junction gamma-1 protein
UniProt accession	P36383
Gene	GJC1
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (146)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
self reported educational attainment · score 0.27
male reproductive organ cancer · score 0.25
platelet component distribution width · score 0.20
cognitive function measurement · score 0.19
systolic blood pressure · score 0.16
lung adenocarcinoma · score 0.14
hypertrophic cardiomyopathy · score 0.06
left ventricular noncompaction · score 0.06
congenital heart disease · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P36383-F1	alphafold	PREDICTED	69.45	—

Amino-acid sequence (396 residues)

MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA KMEHGEADKK AARSKPYAMR WKQHRALEET EEDNEEDPMM YPEMELESDK ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLIGQYFLYG FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ YTELSNAKIA YKQNKANTAQ EQQYGSHEEN LPADLEALQR EIRMAQERLD LAVQAYSHQN NPHGPREKKA KVGSKAGSNK STASSKSGDG KTSVWI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards