About Transcription factor 7
Transcription factor 7 (TCF7) is a protein
from Homo sapiens identified by UniProt accession
P36402, 384 residues long.
MolForge cross-references it against 0 known binders and
282 disease associations.
Target properties
| Protein name | Transcription factor 7 |
|---|
| UniProt accession | P36402 |
|---|
| Gene | TCF7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 384 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (282)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.46
- neurodegenerative disease · score 0.44
- hypothyroidism · score 0.41
- systemic lupus erythematosus · score 0.36
- Hashimoto's thyroiditis · score 0.34
- thyroid disease · score 0.34
- rheumatoid arthritis · score 0.32
- Thyroid preparation use measurement · score 0.31
- cup-to-disc ratio measurement · score 0.28
- autoimmune disease · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36402-F1 | alphafold | PREDICTED | 57.08 | — |
Amino-acid sequence (384 residues)
MPQLDSGGGG AGGGDDLGAP DELLAFQDEG EEQDDKSRDS AAGPERDLAE LKSSLVNESE GAAGGAGIPG VPGAGAGARG EAEALGREHA AQRLFPDKLP EPLEDGLKAP ECTSGMYKET VYSAFNLLMH YPPPSGAGQH PQPQPPLHKA NQPPHGVPQL SLYEHFNSPH PTPAPADISQ KQVHRPLQTP DLSGFYSLTS GSMGQLPHTV SWFTHPSLML GSGVPGHPAA IPHPAIVPPS GKQELQPFDR NLKTQAESKA EKEAKKPTIK KPLNAFMLYM KEMRAKVIAE CTLKESAAIN QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKRRSR EKHQESTTGG KRNAFGTYPE KAAAPAPFLP MTVL
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