About ADP-ribosylation factor-like protein 2
ADP-ribosylation factor-like protein 2 (ARL2) is a protein
from Homo sapiens identified by UniProt accession
P36404, 184 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | ADP-ribosylation factor-like protein 2 |
|---|
| UniProt accession | P36404 |
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| Gene | ARL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 184 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (39)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- MRCS syndrome · score 0.45
- head and neck squamous cell carcinoma · score 0.18
- lung adenocarcinoma · score 0.18
- breast adenocarcinoma · score 0.18
- neoplasm · score 0.08
- calf circumference measurement · score 0.04
- skin basal cell carcinoma · score 0.03
- cancer · score 0.03
- body mass index · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36404-F1 | alphafold | PREDICTED | 94.32 | — |
Amino-acid sequence (184 residues)
MGLLTILKKM KQKERELRLL MLGLDNAGKT TILKKFNGED IDTISPTLGF NIKTLEHRGF KLNIWDVGGQ KSLRSYWRNY FESTDGLIWV VDSADRQRMQ DCQRELQSLL VEERLAGATL LIFANKQDLP GALSSNAIRE VLELDSIRSH HWCIQGCSAV TGENLLPGID WLLDDISSRI FTAD
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