ADP-ribosylation factor-like protein 3 (ARL3)

About ADP-ribosylation factor-like protein 3

ADP-ribosylation factor-like protein 3 (ARL3) is a protein from Homo sapiens identified by UniProt accession P36405, 182 residues long. MolForge cross-references it against 0 known binders and 122 disease associations.

Target properties

Protein name	ADP-ribosylation factor-like protein 3
UniProt accession	P36405
Gene	ARL3
Organism	Homo sapiens
Length	182 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (122)

Diseases linked to this target (Open Targets).

retinitis pigmentosa · score 0.62
Joubert syndrome · score 0.59
cone-rod dystrophy · score 0.46
neurodegenerative disease · score 0.33
blood protein measurement · score 0.31
prostate carcinoma · score 0.21
schizophrenia · score 0.20
genetic disorder · score 0.18
monocyte count · score 0.18
BMI-adjusted waist-hip ratio · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P36405-F1	alphafold	PREDICTED	92.69	—

Amino-acid sequence (182 residues)

MGLLSILRKL KSAPDQEVRI LLLGLDNAGK TTLLKQLASE DISHITPTQG FNIKSVQSQG FKLNVWDIGG QRKIRPYWKN YFENTDILIY VIDSADRKRF EETGQELAEL LEEEKLSCVP VLIFANKQDL LTAAPASEIA EGLNLHTIRD RVWQIQSCSA LTGEGVQDGM NWVCKNVNAK KK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards