About E3 ubiquitin-protein ligase TRIM23
E3 ubiquitin-protein ligase TRIM23 (TRIM23) is a protein
from Homo sapiens identified by UniProt accession
P36406, 574 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase TRIM23 |
|---|
| UniProt accession | P36406 |
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| Gene | TRIM23 |
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| Organism | Homo sapiens |
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| Length | 574 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.22
- neuroimaging measurement · score 0.20
- brain volume measurement · score 0.19
- brain measurement · score 0.18
- body height · score 0.11
- refractive error measurement · score 0.11
- thalamus volume · score 0.11
- reticulocyte measurement · score 0.09
- autism spectrum disorder · score 0.09
- DNA methylation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36406-F1 | alphafold | PREDICTED | 81.71 | — |
Amino-acid sequence (574 residues)
MATLVVNKLG AGVDSGRQGS RGTAVVKVLE CGVCEDVFSL QGDKVPRLLL CGHTVCHDCL TRLPLHGRAI RCPFDRQVTD LGDSGVWGLK KNFALLELLE RLQNGPIGQY GAAEESIGIS GESIIRCDED EAHLASVYCT VCATHLCSEC SQVTHSTKTL AKHRRVPLAD KPHEKTMCSQ HQVHAIEFVC LEEGCQTSPL MCCVCKEYGK HQGHKHSVLE PEANQIRASI LDMAHCIRTF TEEISDYSRK LVGIVQHIEG GEQIVEDGIG MAHTEHVPGT AENARSCIRA YFYDLHETLC RQEEMALSVV DAHVREKLIW LRQQQEDMTI LLSEVSAACL HCEKTLQQDD CRVVLAKQEI TRLLETLQKQ QQQFTEVADH IQLDASIPVT FTKDNRVHIG PKMEIRVVTL GLDGAGKTTI LFKLKQDEFM QPIPTIGFNV ETVEYKNLKF TIWDVGGKHK LRPLWKHYYL NTQAVVFVVD SSHRDRISEA HSELAKLLTE KELRDALLLI FANKQDVAGA LSVEEITELL SLHKLCCGRS WYIQGCDARS GMGLYEGLDW LSRQLVAAGV LDVA
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