About Dual specificity mitogen-activated protein kinase kinase 2
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) is a protein
from Homo sapiens identified by UniProt accession
P36507, 400 residues long.
MolForge cross-references it against 0 known binders and
374 disease associations.
Target properties
| Protein name | Dual specificity mitogen-activated protein kinase kinase 2 |
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| UniProt accession | P36507 |
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| Gene | MAP2K2 |
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| Organism | Homo sapiens |
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| Length | 400 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (374)
Diseases linked to this target (Open Targets).
- cardiofaciocutaneous syndrome · score 0.83
- melanoma · score 0.71
- cancer · score 0.67
- Noonan syndrome · score 0.64
- neoplasm · score 0.56
- rasopathy · score 0.54
- metastatic melanoma · score 0.54
- neurofibromatosis type 1 · score 0.53
- cutaneous melanoma · score 0.51
- hypertrophic cardiomyopathy · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36507-F1 | alphafold | PREDICTED | 81.64 | — |
Amino-acid sequence (400 residues)
MLARRKPVLP ALTINPTIAE GPSPTSEGAS EANLVDLQKK LEELELDEQQ KKRLEAFLTQ KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMAPERLQ GTHYSVQSDI WSMGLSLVEL AVGRYPIPPP DAKELEAIFG RPVVDGEEGE PHSISPRPRP PGRPVSGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTP DFQEFVNKCL IKNPAERADL KMLTNHTFIK RSEVEEVDFA GWLCKTLRLN QPGTPTRTAV
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