About UDP-glucuronosyltransferase 2B10
UDP-glucuronosyltransferase 2B10 (UGT2B10) is a protein
from Homo sapiens identified by UniProt accession
P36537, 528 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 2B10 |
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| UniProt accession | P36537 |
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| Gene | UGT2B10 |
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| Organism | Homo sapiens |
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| Length | 528 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.49
- bilirubin measurement · score 0.43
- cotinine glucuronidation measurement · score 0.43
- cotinine measurement · score 0.41
- mean corpuscular volume · score 0.41
- mean corpuscular hemoglobin concentration · score 0.40
- mean corpuscular hemoglobin · score 0.40
- nicotine glucuronidation measurement · score 0.31
- trans-3-hydroxycotinine measurement · score 0.29
- cigarettes per day measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36537-F1 | alphafold | PREDICTED | 92.40 | — |
Amino-acid sequence (528 residues)
MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH EVTVLASSAS ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ KDTFWLPFSQ EQEILWAIND IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD AYLPCGELLA ELFNIPFVYS HSFSPGYSFE RHSGGFIFPP SYVPVVMSKL SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG RPTTLSETMR KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT RLYKWIPQND LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD NIAHMKAKGA AVRVDFNTMS STDLLNALKT VINDPSYKEN IMKLSRIQHD QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH NLTWFQYHSL DVIGFLLACV ATVLFIITKC CLFCFWKFAR KGKKGKRD
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