About ATP synthase F(1) complex subunit gamma, mitochondrial
ATP synthase F(1) complex subunit gamma, mitochondrial (ATP5F1C) is a protein
from Homo sapiens identified by UniProt accession
P36542, 298 residues long.
MolForge cross-references it against 0 known binders and
34 disease associations.
Target properties
| Protein name | ATP synthase F(1) complex subunit gamma, mitochondrial |
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| UniProt accession | P36542 |
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| Gene | ATP5F1C |
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| Organism | Homo sapiens |
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| Length | 298 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (34)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.10
- mean corpuscular volume · score 0.07
- mean reticulocyte volume · score 0.05
- neoplasm · score 0.03
- red blood cell density measurement · score 0.02
- pentraxin-related protein PTX3 measurement · score 0.02
- Alzheimer disease · score 0.01
- bacteriemia · score 0.01
- cancer · score 0.01
- ovarian carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36542-F1 | alphafold | PREDICTED | 87.90 | — |
Amino-acid sequence (298 residues)
MFSRAGVAGL SAWTLQPQWI QVRNMATLKD ITRRLKSIKN IQKITKSMKM VAAAKYARAE RELKPARIYG LGSLALYEKA DIKGPEDKKK HLLIGVSSDR GLCGAIHSSI AKQMKSEVAT LTAAGKEVML VGIGDKIRGI LYRTHSDQFL VAFKEVGRKP PTFGDASVIA LELLNSGYEF DEGSIIFNKF RSVISYKTEE KPIFSLNTVA SADSMSIYDD IDADVLQNYQ EYNLANIIYY SLKESTTSEQ SARMTAMDNA SKNASEMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD
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