About V-type proton ATPase subunit E 1
V-type proton ATPase subunit E 1 (ATP6V1E1) is a protein
from Homo sapiens identified by UniProt accession
P36543, 226 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | V-type proton ATPase subunit E 1 |
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| UniProt accession | P36543 |
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| Gene | ATP6V1E1 |
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| Organism | Homo sapiens |
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| Length | 226 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- autosomal recessive cutis laxa type 2, classic type · score 0.53
- neurodegenerative disease · score 0.48
- autosomal recessive cutis laxa type 2 · score 0.44
- cutis laxa · score 0.34
- rasopathy · score 0.34
- breast adenocarcinoma · score 0.21
- eosinophil count · score 0.08
- neutrophil count · score 0.08
- leukocyte count · score 0.07
- serum alanine aminotransferase measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36543-F1 | alphafold | PREDICTED | 94.96 | — |
Amino-acid sequence (226 residues)
MALSDADVQK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR LKIMEYYEKK EKQIEQQKKI QMSNLMNQAR LKVLRARDDL ITDLLNEAKQ RLSKVVKDTT RYQVLLDGLV LQGLYQLLEP RMIVRCRKQD FPLVKAAVQK AIPMYKIATK NDVDVQIDQE SYLPEDIAGG VEIYNGDRKI KVSNTLESRL DLIAQQMMPE VRGALFGANA NRKFLD
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