About Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (CPOX) is a protein
from Homo sapiens identified by UniProt accession
P36551, 454 residues long.
MolForge cross-references it against 0 known binders and
317 disease associations.
Target properties
| Protein name | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial |
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| UniProt accession | P36551 |
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| Gene | CPOX |
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| Organism | Homo sapiens |
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| Length | 454 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (317)
Diseases linked to this target (Open Targets).
- hereditary coproporphyria · score 0.81
- harderoporphyria · score 0.77
- neurodegenerative disease · score 0.53
- CPOX-related hereditary coproporphyria · score 0.44
- genetic disorder · score 0.19
- early-onset non-syndromic cataract · score 0.11
- total blood protein measurement · score 0.11
- hereditary hyperferritinemia with congenital cataracts · score 0.10
- isolated ectopia lentis · score 0.10
- Blackfan-Diamond anemia · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36551-F1 | alphafold | PREDICTED | 78.65 | — |
Amino-acid sequence (454 residues)
MALQLGRLSS GPCWLVARGG CGGPRAWSQC GGGGLRAWSQ RSAAGRVCRP PGPAGTEQSR GLGHGSTSRG GPWVGTGLAA ALAGLVGLAT AAFGHVQRAE MLPKTSGTRA TSLGRPEEEE DELAHRCSSF MAPPVTDLGE LRRRPGDMKT KMELLILETQ AQVCQALAQV DGGANFSVDR WERKEGGGGI SCVLQDGCVF EKAGVSISVV HGNLSEEAAK QMRSRGKVLK TKDGKLPFCA MGVSSVIHPK NPHAPTIHFN YRYFEVEEAD GNKQWWFGGG CDLTPTYLNQ EDAVHFHRTL KEACDQHGPD LYPKFKKWCD DYFFIAHRGE RRGIGGIFFD DLDSPSKEEV FRFVQSCARA VVPSYIPLVK KHCDDSFTPQ EKLWQQLRRG RYVEFNLLYD RGTKFGLFTP GSRIESILMS LPLTARWEYM HSPSENSKEA EILEVLRHPR DWVR
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