About Arrestin-C
Arrestin-C (ARR3) is a protein
from Homo sapiens identified by UniProt accession
P36575, 388 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Arrestin-C |
|---|
| UniProt accession | P36575 |
|---|
| Gene | ARR3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 388 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- myopia 26, X-linked, female-limited · score 0.59
- Rare isolated myopia · score 0.46
- refractive error · score 0.19
- genetic disorder · score 0.19
- neoplasm · score 0.08
- Myopia · score 0.05
- myopia · score 0.05
- respiratory depression · score 0.04
- hypertriglyceridemia 2 · score 0.04
- adolescent idiopathic scoliosis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36575-F1 | alphafold | PREDICTED | 86.76 | — |
Amino-acid sequence (388 residues)
MSKVFKKTSS NGKLSIYLGK RDFVDHVDTV EPIDGVVLVD PEYLKCRKLF VMLTCAFRYG RDDLEVIGLT FRKDLYVQTL QVVPAESSSP QGPLTVLQER LLHKLGDNAY PFTLQMVTNL PCSVTLQPGP EDAGKPCGID FEVKSFCAEN PEETVSKRDY VRLVVRKVQF APPEAGPGPS AQTIRRFLLS AQPLQLQAWM DREVHYHGEP ISVNVSINNC TNKVIKKIKI SVDQITDVVL YSLDKYTKTV FIQEFTETVA ANSSFSQSFA VTPILAASCQ KRGLALDGKL KHEDTNLASS TIIRPGMDKE LLGILVSYKV RVNLMVSCGG ILGDLTASDV GVELPLVLIH PKPSHEAASS EDIVIEEFTR KGEEESQKAV EAEGDEGS
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