Large ribosomal subunit protein uL4 (RPL4)

About Large ribosomal subunit protein uL4

Large ribosomal subunit protein uL4 (RPL4) is a protein from Homo sapiens identified by UniProt accession P36578, 427 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Large ribosomal subunit protein uL4
UniProt accession	P36578
Gene	RPL4
Organism	Homo sapiens
Length	427 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
Becker muscular dystrophy · score 0.29
clear cell renal carcinoma · score 0.27
endometrial cancer · score 0.27
qualitative or quantitative defects of dystrophin · score 0.26
acute myeloid leukemia · score 0.22
thyroid gland adenocarcinoma · score 0.18
hypertension · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P36578-F1	alphafold	PREDICTED	87.11	—

Amino-acid sequence (427 residues)

MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQG AFGNMCRGGR MFAPTKTWRR WHRRVNTTQK RYAICSALAA SALPALVMSK GHRIEEVPEL PLVVEDKVEG YKKTKEAVLL LKKLKAWNDI KKVYASQRMR AGKGKMRNRR RIQRRGPCII YNEDNGIIKA FRNIPGITLL NVSKLNILKL APGGHVGRFC IWTESAFRKL DELYGTWRKA ASLKSNYNLP MHKMINTDLS RILKSPEIQR ALRAPRKKIH RRVLKKNPLK NLRIMLKLNP YAKTMRRNTI LRQARNHKLR VDKAAAAAAA LQAKSDEKAA VAGKKPVVGK KGKKAAVGVK KQKKPLVGKK AAATKKPAPE KKPAEKKPTT EEKKPAA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards