About Phosphoglucomutase-1
Phosphoglucomutase-1 (PGM1) is a protein
from Homo sapiens identified by UniProt accession
P36871, 562 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Phosphoglucomutase-1 |
|---|
| UniProt accession | P36871 |
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| Gene | PGM1 |
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| Organism | Homo sapiens |
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| Length | 562 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (151)
Diseases linked to this target (Open Targets).
- PGM1-congenital disorder of glycosylation · score 0.85
- congenital disorder of glycosylation · score 0.66
- disorder of glycogen metabolism · score 0.50
- Glycogen storage disease due to phosphoglucomutase deficiency · score 0.50
- congenital disorder of deglycosylation · score 0.50
- genetic disorder · score 0.45
- serum gamma-glutamyl transferase measurement · score 0.41
- type 2 diabetes mellitus · score 0.41
- type 1 diabetes mellitus · score 0.40
- protein measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36871-F1 | alphafold | PREDICTED | 97.12 | — |
Amino-acid sequence (562 residues)
MVKIVTVKTQ AYQDQKPGTS GLRKRVKVFQ SSANYAENFI QSIISTVEPA QRQEATLVVG GDGRFYMKEA IQLIARIAAA NGIGRLVIGQ NGILSTPAVS CIIRKIKAIG GIILTASHNP GGPNGDFGIK FNISNGGPAP EAITDKIFQI SKTIEEYAVC PDLKVDLGVL GKQQFDLENK FKPFTVEIVD SVEAYATMLR SIFDFSALKE LLSGPNRLKI RIDAMHGVVG PYVKKILCEE LGAPANSAVN CVPLEDFGGH HPDPNLTYAA DLVETMKSGE HDFGAAFDGD GDRNMILGKH GFFVNPSDSV AVIAANIFSI PYFQQTGVRG FARSMPTSGA LDRVASATKI ALYETPTGWK FFGNLMDASK LSLCGEESFG TGSDHIREKD GLWAVLAWLS ILATRKQSVE DILKDHWQKY GRNFFTRYDY EEVEAEGANK MMKDLEALMF DRSFVGKQFS ANDKVYTVEK ADNFEYSDPV DGSISRNQGL RLIFTDGSRI VFRLSGTGSA GATIRLYIDS YEKDVAKINQ DPQVMLAPLI SIALKVSQLQ ERTGRTAPTV IT
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