About Bone morphogenetic protein receptor type-1A
Bone morphogenetic protein receptor type-1A (BMPR1A) is a protein
from Homo sapiens identified by UniProt accession
P36894, 532 residues long.
MolForge cross-references it against 0 known binders and
343 disease associations.
Target properties
| Protein name | Bone morphogenetic protein receptor type-1A |
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| UniProt accession | P36894 |
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| Gene | BMPR1A |
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| Organism | Homo sapiens |
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| Length | 532 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (343)
Diseases linked to this target (Open Targets).
- juvenile polyposis syndrome · score 0.82
- hereditary mixed polyposis syndrome · score 0.73
- generalized juvenile polyposis/juvenile polyposis coli · score 0.63
- hereditary neoplastic syndrome · score 0.58
- Inherited cancer-predisposing syndrome · score 0.57
- tibia fracture · score 0.50
- bone disease · score 0.46
- neurodegenerative disease · score 0.42
- BMI-adjusted waist circumference · score 0.39
- kidney neoplasm · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36894-F1 | alphafold | PREDICTED | 82.61 | — |
Amino-acid sequence (532 residues)
MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVLLISM AVCIIAMIIF SSCFCYKHYC KSISSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
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