About Activin receptor type-1B
Activin receptor type-1B (ACVR1B) is a protein
from Homo sapiens identified by UniProt accession
P36896, 505 residues long.
MolForge cross-references it against 0 known binders and
244 disease associations.
Target properties
| Protein name | Activin receptor type-1B |
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| UniProt accession | P36896 |
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| Gene | ACVR1B |
|---|
| Organism | Homo sapiens |
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| Length | 505 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (244)
Diseases linked to this target (Open Targets).
- pancreatic carcinoma · score 0.49
- pancreatic neoplasm · score 0.42
- familial pancreatic carcinoma · score 0.42
- pancreatic adenocarcinoma · score 0.42
- nodular melanoma · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- colorectal adenocarcinoma · score 0.37
- Ampulla of Vater Carcinoma · score 0.37
- breast ductal adenocarcinoma · score 0.37
- carcinoma of liver and intrahepatic biliary tract · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36896-F1 | alphafold | PREDICTED | 83.37 | — |
Amino-acid sequence (505 residues)
MAESAGASSF FPLVVLLLAG SGGSGPRGVQ ALLCACTSCL QANYTCETDG ACMVSIFNLD GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY CNRIDLRVPS GHLKEPEHPS MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNIPNWW QSYEALRVMG KMMRECWYAN GAARLTALRI KKTLSQLSVQ EDVKI
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