About TGF-beta receptor type-1
TGF-beta receptor type-1 (TGFBR1) is a protein
from Homo sapiens identified by UniProt accession
P36897, 503 residues long.
MolForge cross-references it against 0 known binders and
608 disease associations.
Target properties
| Protein name | TGF-beta receptor type-1 |
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| UniProt accession | P36897 |
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| Gene | TGFBR1 |
|---|
| Organism | Homo sapiens |
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| Length | 503 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (608)
Diseases linked to this target (Open Targets).
- Loeys-Dietz syndrome 1 · score 0.81
- Loeys-Dietz syndrome · score 0.75
- multiple self-healing squamous epithelioma · score 0.72
- familial thoracic aortic aneurysm and aortic dissection · score 0.71
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.57
- cancer · score 0.55
- Alzheimer disease · score 0.46
- Parkinson disease · score 0.46
- multiple sclerosis · score 0.45
- lysosomal storage disease · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36897-F1 | alphafold | PREDICTED | 84.19 | — |
Amino-acid sequence (503 residues)
MEAAVAAPRP RLLLLVLAAA AAAAAALLPG ATALQCFCHL CTKDNFTCVT DGLCFVSVTE TTDKVIHNSM CIAEIDLIPR DRPFVCAPSS KTGSVTTTYC CNQDHCNKIE LPTTVKSSPG LGPVELAAVI AGPVCFVCIS LMLMVYICHN RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA ARLTALRIKK TLSQLSQQEG IKM
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