About Guanine nucleotide-binding protein-like 1
Guanine nucleotide-binding protein-like 1 (GNL1) is a protein
from Homo sapiens identified by UniProt accession
P36915, 607 residues long.
MolForge cross-references it against 0 known binders and
45 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein-like 1 |
|---|
| UniProt accession | P36915 |
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| Gene | GNL1 |
|---|
| Organism | Homo sapiens |
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| Length | 607 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (45)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.24
- platelet-to-lymphocyte ratio · score 0.19
- mean corpuscular hemoglobin · score 0.18
- psoriasis · score 0.12
- Oral ulcer · score 0.07
- cancer · score 0.06
- influenza A (H1N1) · score 0.04
- hemoglobin measurement · score 0.04
- autism spectrum disorder · score 0.03
- schizophrenia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36915-F1 | alphafold | PREDICTED | 76.75 | — |
Amino-acid sequence (607 residues)
MPRKKPFSVK QKKKQLQDKR ERKRGLQDGL RSSSNSRSGS RERREEQTDT SDGESVTHHI RRLNQQPSQG LGPRGYDPNR YRLHFERDSR EEVERRKRAA REQVLQPVSA ELLELDIREV YQPGSVLDFP RRPPWSYEMS KEQLMSQEER SFQDYLGKIH GAYSSEKLSY FEHNLETWRQ LWRVLEMSDI VLLITDIRHP VVNFPPALYE YVTGELGLAL VLVLNKVDLA PPALVVAWKH YFHQHYPQLH VVLFTSFPRD PRTPQDPSSV LKKSRRRGRG WTRALGPEQL LRACEAITVG KVDLSSWREK IARDVAGATW GNGSGEEEEE EDGPAVLVEQ QTDSAMEPTG PTQERYKDGV VTIGCVGFPN VGKSSLINGL VGRKVVSVSR TPGHTRYFQT YFLTPSVKLC DCPGLIFPSL LPRQLQVLAG IYPIAQIQEP YTAVGYLASR IPVQALLHLR HPEAEDPSAE HPWCAWDICE AWAEKRGYKT AKAARNDVYR AANSLLRLAV DGRLSLCFHP PGYSEQKGTW ESHPETTELV VLQGRVGPAG DEEEEEEEEL SSSCEEEGEE DRDADEEGEG DEETPTSAPG SSLAGRNPYA LLGEDEC
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