Serpin B5 (SERPINB5)

About Serpin B5

Serpin B5 (SERPINB5) is a protein from Homo sapiens identified by UniProt accession P36952, 375 residues long. MolForge cross-references it against 0 known binders and 288 disease associations.

Target properties

Protein name	Serpin B5
UniProt accession	P36952
Gene	SERPINB5
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (288)

Diseases linked to this target (Open Targets).

PHF-tau measurement · score 0.20
monocyte percentage of leukocytes · score 0.13
neoplasm · score 0.12
hepatocellular carcinoma · score 0.10
non-small cell lung carcinoma · score 0.10
lung adenocarcinoma · score 0.10
urinary bladder carcinoma · score 0.09
skin basal cell carcinoma · score 0.08
cancer · score 0.08
esophageal squamous cell carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P36952-F1	alphafold	PREDICTED	95.16	—

Amino-acid sequence (375 residues)

MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFSESET KECPFRVNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTRNIIFFG KFCSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards