DNA-directed RNA polymerase II subunit RPB9 (POLR2I)

About DNA-directed RNA polymerase II subunit RPB9

DNA-directed RNA polymerase II subunit RPB9 (POLR2I) is a protein from Homo sapiens identified by UniProt accession P36954, 125 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	DNA-directed RNA polymerase II subunit RPB9
UniProt accession	P36954
Gene	POLR2I
Organism	Homo sapiens
Length	125 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

HIV infection · score 0.60
acrocephalosyndactyly · score 0.37
influenza · score 0.37
breast adenocarcinoma · score 0.28
clear cell renal carcinoma · score 0.27
cutaneous melanoma · score 0.24
ovarian cancer · score 0.18
urinary bladder cancer · score 0.12
membranous glomerulonephritis · score 0.06
schizophrenia · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P36954-F1	alphafold	PREDICTED	85.73	—

Amino-acid sequence (125 residues)

MEPDGTYEPG FVGIRFCQEC NNMLYPKEDK ENRILLYACR NCDYQQEADN SCIYVNKITH EVDELTQIIA DVSQDPTLPR TEDHPCQKCG HKEAVFFQSH SARAEDAMRL YYVCTAPHCG HRWTE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards