Pigment epithelium-derived factor (SERPINF1)

About Pigment epithelium-derived factor

Pigment epithelium-derived factor (SERPINF1) is a protein from Homo sapiens identified by UniProt accession P36955, 418 residues long. MolForge cross-references it against 0 known binders and 480 disease associations.

Target properties

Protein name	Pigment epithelium-derived factor
UniProt accession	P36955
Gene	SERPINF1
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (480)

Diseases linked to this target (Open Targets).

osteogenesis imperfecta · score 0.68
osteogenesis imperfecta type 3 · score 0.45
blood protein measurement · score 0.39
osteogenesis imperfecta type 4 · score 0.37
body height · score 0.36
neurodegenerative disease · score 0.33
forced expiratory volume · score 0.32
vital capacity · score 0.30
Abnormality of the skeletal system · score 0.27
lean body mass · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P36955-F1	alphafold	PREDICTED	90.10	—

Amino-acid sequence (418 residues)

MQALVLLLCI GALLGHSSCQ NPASPPEEGS PDPDSTGALV EEEDPFFKVP VNKLAAAVSN FGYDLYRVRS STSPTTNVLL SPLSVATALS ALSLGAEQRT ESIIHRALYY DLISSPDIHG TYKELLDTVT APQKNLKSAS RIVFEKKLRI KSSFVAPLEK SYGTRPRVLT GNPRLDLQEI NNWVQAQMKG KLARSTKEIP DEISILLLGV AHFKGQWVTK FDSRKTSLED FYLDEERTVR VPMMSDPKAV LRYGLDSDLS CKIAQLPLTG SMSIIFFLPL KVTQNLTLIE ESLTSEFIHD IDRELKTVQA VLTVPKLKLS YEGEVTKSLQ EMKLQSLFDS PDFSKITGKP IKLTQVEHRA GFEWNEDGAG TTPSPGLQPA HLTFPLDYHL NQPFIFVLRD TDTGALLFIG KILDPRGP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards