About GMP reductase 1
GMP reductase 1 (GMPR) is a protein
from Homo sapiens identified by UniProt accession
P36959, 345 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | GMP reductase 1 |
|---|
| UniProt accession | P36959 |
|---|
| Gene | GMPR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 345 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.72
- reticulocyte measurement · score 0.71
- mean corpuscular volume · score 0.70
- mean corpuscular hemoglobin · score 0.70
- Red cell distribution width · score 0.66
- mean corpuscular hemoglobin concentration · score 0.66
- erythrocyte count · score 0.61
- hemoglobin measurement · score 0.58
- Immature Reticulocyte Fraction Measurement · score 0.49
- red blood cell density measurement · score 0.42
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P36959-F1 | alphafold | PREDICTED | 97.01 | — |
Amino-acid sequence (345 residues)
MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI IVANMDTVGT FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA VSSGSGQNDL EKMTSILEAV PQVKFICLDV ANGYSEHFVE FVKLVRAKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE CAGEVFERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS
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