About Phospholipid hydroperoxide glutathione peroxidase GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) is a protein
from Homo sapiens identified by UniProt accession
P36969, 197 residues long.
MolForge cross-references it against 0 known binders and
595 disease associations.
Target properties
| Protein name | Phospholipid hydroperoxide glutathione peroxidase GPX4 |
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| UniProt accession | P36969 |
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| Gene | GPX4 |
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| Organism | Homo sapiens |
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| Length | 197 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (595)
Diseases linked to this target (Open Targets).
- spondylometaphyseal dysplasia, Sedaghatian type · score 0.70
- neurodegenerative disease · score 0.46
- eosinophil count · score 0.38
- eosinophil percentage of leukocytes · score 0.35
- Crohn's disease · score 0.27
- Nasal Cavity Polyp · score 0.24
- eosinophil percentage of granulocytes · score 0.24
- sum of eosinophil and basophil counts · score 0.24
- neutrophil percentage of granulocytes · score 0.24
- lymphocyte count · score 0.23
Amino-acid sequence (197 residues)
MSLGRLCRLL KPALLCGALA APGLAGTMCA SRDDWRCARS MHEFSAKDID GHMVNLDKYR GFVCIVTNVA SQUGKTEVNY TQLVDLHARY AECGLRILAF PCNQFGKQEP GSNEEIKEFA AGYNVKFDMF SKICVNGDDA HPLWKWMKIQ PKGKGILGNA IKWNFTKFLI DKNGCVVKRY GPMEEPLVIE KDLPHYF
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