Complement factor H-related protein 2 (CFHR2)

About Complement factor H-related protein 2

Complement factor H-related protein 2 (CFHR2) is a protein from Homo sapiens identified by UniProt accession P36980, 270 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Complement factor H-related protein 2
UniProt accession	P36980
Gene	CFHR2
Organism	Homo sapiens
Length	270 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

non-immunoglobulin-mediated membranoproliferative glomerulonephritis · score 0.46
complement factor H-related protein 2 measurement · score 0.42
age-related macular degeneration · score 0.41
sex hormone-binding globulin measurement · score 0.33
blood protein measurement · score 0.30
coagulation factor measurement · score 0.26
complement factor H-related protein 3 measurement · score 0.25
systolic blood pressure · score 0.24
high density lipoprotein cholesterol measurement · score 0.23
mean arterial pressure · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P36980-F1	alphafold	PREDICTED	90.65	—

Amino-acid sequence (270 residues)

MWLLVSVILI SRISSVGGEA MFCDFPKINH GILYDEEKYK PFSQVPTGEV FYYSCEYNFV SPSKSFWTRI TCAEEGWSPT PKCLRLCFFP FVENGHSESS GQTHLEGDTV QIICNTGYRL QNNENNISCV ERGWSTPPKC RSTISAEKCG PPPPIDNGDI TSFLLSVYAP GSSVEYQCQN LYQLEGNNQI TCRNGQWSEP PKCLDPCVIS QEIMEKYNIK LKWTNQQKLY SRTGDIVEFV CKSGYHPTKS HSFRAMCQNG KLVYPSCEEK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards