About Activin receptor type-1-like
Activin receptor type-1-like (ACVRL1) is a protein
from Homo sapiens identified by UniProt accession
P37023, 503 residues long.
MolForge cross-references it against 0 known binders and
239 disease associations.
Target properties
| Protein name | Activin receptor type-1-like |
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| UniProt accession | P37023 |
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| Gene | ACVRL1 |
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| Organism | Homo sapiens |
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| Length | 503 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (239)
Diseases linked to this target (Open Targets).
- hereditary hemorrhagic telangiectasia · score 0.83
- pulmonary arterial hypertension · score 0.61
- vascular disease · score 0.59
- Abnormality of the cardiovascular system · score 0.56
- pulmonary hypertension, primary, 1 · score 0.52
- heritable pulmonary arterial hypertension · score 0.49
- epistaxis · score 0.49
- capillary disorder · score 0.43
- hematocrit · score 0.41
- neutrophil count · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P37023-F1 | alphafold | PREDICTED | 81.98 | — |
Amino-acid sequence (503 residues)
MTLGSPRKGL LMLLMALVTQ GDPVKPSRGP LVTCTCESPH CKGPTCRGAW CTVVLVREEG RHPQEHRGCG NLHRELCRGR PTEFVNHYCC DSHLCNHNVS LVLEATQPPS EQPGTDGQLA LILGPVLALL ALVALGVLGL WHVRRRQEKQ RGLHSELGES SLILKASEQG DSMLGDLLDS DCTTGSGSGL PFLVQRTVAR QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF RETEIYNTVL LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPHLAL RLAVSAACGL AHLHVEIFGT QGKPAIAHRD FKSRNVLVKS NLQCCIADLG LAVMHSQGSD YLDIGNNPRV GTKRYMAPEV LDEQIRTDCF ESYKWTDIWA FGLVLWEIAR RTIVNGIVED YRPPFYDVVP NDPSFEDMKK VVCVDQQTPT IPNRLAADPV LSGLAQMMRE CWYPNPSARL TALRIKKTLQ KISNSPEKPK VIQ
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