About 17-beta-hydroxysteroid dehydrogenase type 3
17-beta-hydroxysteroid dehydrogenase type 3 (HSD17B3) is a protein
from Homo sapiens identified by UniProt accession
P37058, 310 residues long.
MolForge cross-references it against 0 known binders and
194 disease associations.
Target properties
| Protein name | 17-beta-hydroxysteroid dehydrogenase type 3 |
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| UniProt accession | P37058 |
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| Gene | HSD17B3 |
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| Organism | Homo sapiens |
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| Length | 310 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (194)
Diseases linked to this target (Open Targets).
- 46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency · score 0.82
- pseudohermaphroditism · score 0.52
- genetic disorder · score 0.50
- disorder of sexual differentiation · score 0.40
- Genetic 46,XY disorder of sex development · score 0.40
- juvenile myoclonic epilepsy · score 0.34
- neurofibrillary tangles measurement · score 0.22
- cortical surface area measurement · score 0.21
- head and neck squamous cell carcinoma · score 0.11
- FEV/FVC ratio · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P37058-F1 | alphafold | PREDICTED | 93.78 | — |
Amino-acid sequence (310 residues)
MGDVLEQFFI LTGLLVCLAC LAKCVRFSRC VLLNYWKVLP KSFLRSMGQW AVITGAGDGI GKAYSFELAK RGLNVVLISR TLEKLEAIAT EIERTTGRSV KIIQADFTKD DIYEHIKEKL AGLEIGILVN NVGMLPNLLP SHFLNAPDEI QSLIHCNITS VVKMTQLILK HMESRQKGLI LNISSGIALF PWPLYSMYSA SKAFVCAFSK ALQEEYKAKE VIIQVLTPYA VSTAMTKYLN TNVITKTADE FVKESLNYVT IGGETCGCLA HEILAGFLSL IPAWAFYSGA FQRLLLTHYV AYLKLNTKVR
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