About Epithelial sodium channel subunit alpha
Epithelial sodium channel subunit alpha (SCNN1A) is a protein
from Homo sapiens identified by UniProt accession
P37088, 669 residues long.
MolForge cross-references it against 0 known binders and
197 disease associations.
Target properties
| Protein name | Epithelial sodium channel subunit alpha |
|---|
| UniProt accession | P37088 |
|---|
| Gene | SCNN1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 669 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (197)
Diseases linked to this target (Open Targets).
- autosomal recessive pseudohypoaldosteronism type 1 · score 0.77
- Bronchiectasis · score 0.74
- Generalized pseudohypoaldosteronism type 1 · score 0.72
- hypertension · score 0.60
- congestive heart failure · score 0.59
- cardiac arrhythmia · score 0.58
- Liddle syndrome 2 · score 0.51
- edema · score 0.50
- chronic kidney disease · score 0.46
- bronchiectasis · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P37088-F1 | alphafold | PREDICTED | 74.57 | — |
Amino-acid sequence (669 residues)
MEGNKLEEQD SSPPQSTPGL MKGNKREEQG LGPEPAAPQQ PTAEEEALIE FHRSYRELFE FFCNNTTIHG AIRLVCSQHN RMKTAFWAVL WLCTFGMMYW QFGLLFGEYF SYPVSLNINL NSDKLVFPAV TICTLNPYRY PEIKEELEEL DRITEQTLFD LYKYSSFTTL VAGSRSRRDL RGTLPHPLQR LRVPPPPHGA RRARSVASSL RDNNPQVDWK DWKIGFQLCN QNKSDCFYQT YSSGVDAVRE WYRFHYINIL SRLPETLPSL EEDTLGNFIF ACRFNQVSCN QANYSHFHHP MYGNCYTFND KNNSNLWMSS MPGINNGLSL MLRAEQNDFI PLLSTVTGAR VMVHGQDEPA FMDDGGFNLR PGVETSISMR KETLDRLGGD YGDCTKNGSD VPVENLYPSK YTQQVCIHSC FQESMIKECG CAYIFYPRPQ NVEYCDYRKH SSWGYCYYKL QVDFSSDHLG CFTKCRKPCS VTSYQLSAGY SRWPSVTSQE WVFQMLSRQN NYTVNNKRNG VAKVNIFFKE LNYKTNSESP SVTMVTLLSN LGSQWSLWFG SSVLSVVEMA ELVFDLLVIM FLMLLRRFRS RYWSPGRGGR GAQEVASTLA SSPPSHFCPH PMSLSLSQPG PAPSPALTAP PPAYATLGPR PSPGGSAGAS SSTCPLGGP
Explore Epithelial sodium channel subunit alpha with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets