About TGF-beta receptor type-2
TGF-beta receptor type-2 (TGFBR2) is a protein
from Homo sapiens identified by UniProt accession
P37173, 567 residues long.
MolForge cross-references it against 0 known binders and
742 disease associations.
Target properties
| Protein name | TGF-beta receptor type-2 |
|---|
| UniProt accession | P37173 |
|---|
| Gene | TGFBR2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 567 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (742)
Diseases linked to this target (Open Targets).
- Loeys-Dietz syndrome · score 0.82
- Marfan syndrome type 2 · score 0.80
- familial thoracic aortic aneurysm and aortic dissection · score 0.71
- esophageal squamous cell carcinoma · score 0.67
- pancreatic adenocarcinoma · score 0.57
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.57
- neurodegenerative disease · score 0.57
- Lynch syndrome · score 0.56
- cancer · score 0.54
- breast carcinoma · score 0.51
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P37173-F1 | alphafold | PREDICTED | 80.98 | — |
Amino-acid sequence (567 residues)
MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SVNNDMIVTD NNGAVKFPQL CKFCDVRFST CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDAASPK CIMKEKKKPG ETFFMCSCSS DECNDNIIFS EEYNTSNPDL LLVIFQVTGI SLLPPLGVAI SVIIIFYCYR VNRQQKLSST WETGKTRKLM EFSEHCAIIL EDDRSDISST CANNINHNTE LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDINLK HENILQFLTA EERKTELGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG TARYMAPEVL ESRMNLENVE SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QMVCETLTEC WDHDPEARLT AQCVAERFSE LEHLDRLSGR SCSEEKIPED GSLNTTK
Explore TGF-beta receptor type-2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets