Squalene synthase (FDFT1)

About Squalene synthase

Squalene synthase (FDFT1) is a protein from Homo sapiens identified by UniProt accession P37268, 417 residues long. MolForge cross-references it against 0 known binders and 169 disease associations.

Target properties

Protein name	Squalene synthase
UniProt accession	P37268
Gene	FDFT1
Organism	Homo sapiens
Length	417 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (169)

Diseases linked to this target (Open Targets).

squalene synthase deficiency · score 0.51
Hypercholesterolemia · score 0.40
reticulocyte count · score 0.35
C-reactive protein measurement · score 0.34
Disorder of lipid metabolism · score 0.32
mean corpuscular volume · score 0.32
blood protein measurement · score 0.29
reticulocyte measurement · score 0.29
triglyceride measurement · score 0.29
mean reticulocyte volume · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P37268-F1	alphafold	PREDICTED	89.14	—

Amino-acid sequence (417 residues)

MEFVKCLGHP EEFYNLVRFR IGGKRKVMPK MDQDSLSSSL KTCYKYLNQT SRSFAAVIQA LDGEMRNAVC IFYLVLRALD TLEDDMTISV EKKVPLLHNF HSFLYQPDWR FMESKEKDRQ VLEDFPTISL EFRNLAEKYQ TVIADICRRM GIGMAEFLDK HVTSEQEWDK YCHYVAGLVG IGLSRLFSAS EFEDPLVGED TERANSMGLF LQKTNIIRDY LEDQQGGREF WPQEVWSRYV KKLGDFAKPE NIDLAVQCLN ELITNALHHI PDVITYLSRL RNQSVFNFCA IPQVMAIATL AACYNNQQVF KGAVKIRKGQ AVTLMMDATN MPAVKAIIYQ YMEEIYHRIP DSDPSSSKTR QIISTIRTQN LPNCQLISRS HYSPIYLSFV MLLAALSWQY LTTLSQVTED YVQTGEH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards