About Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIGA) is a protein
from Homo sapiens identified by UniProt accession
P37287, 484 residues long.
MolForge cross-references it against 0 known binders and
133 disease associations.
Target properties
| Protein name | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A |
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| UniProt accession | P37287 |
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| Gene | PIGA |
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| Organism | Homo sapiens |
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| Length | 484 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (133)
Diseases linked to this target (Open Targets).
- multiple congenital anomalies-hypotonia-seizures syndrome 2 · score 0.81
- Multiple congenital anomalies-hypotonia-seizures syndrome type 2 · score 0.68
- paroxysmal nocturnal hemoglobinuria 1 · score 0.68
- paroxysmal nocturnal hemoglobinuria · score 0.52
- ferro-cerebro-cutaneous syndrome · score 0.46
- malignant migrating partial seizures of infancy · score 0.37
- West syndrome · score 0.37
- genetic disorder · score 0.34
- Epileptic encephalopathy · score 0.27
- Intellectual disability · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P37287-F1 | alphafold | PREDICTED | 85.68 | — |
Amino-acid sequence (484 residues)
MACRGGAGNG HRASATLSRV SPGSLYTCRT RTHNICMVSD FFYPNMGGVE SHIYQLSQCL IERGHKVIIV THAYGNRKGI RYLTSGLKVY YLPLKVMYNQ STATTLFHSL PLLRYIFVRE RVTIIHSHSS FSAMAHDALF HAKTMGLQTV FTDHSLFGFA DVSSVLTNKL LTVSLCDTNH IICVSYTSKE NTVLRAALNP EIVSVIPNAV DPTDFTPDPF RRHDSITIVV VSRLVYRKGI DLLSGIIPEL CQKYPDLNFI IGGEGPKRII LEEVRERYQL HDRVRLLGAL EHKDVRNVLV QGHIFLNTSL TEAFCMAIVE AASCGLQVVS TRVGGIPEVL PENLIILCEP SVKSLCEGLE KAIFQLKSGT LPAPENIHNI VKTFYTWRNV AERTEKVYDR VSVEAVLPMD KRLDRLISHC GPVTGYIFAL LAVFNFLFLI FLRWMTPDSI IDVAIDATGP RGAWTNNYSH SKRGGENNEI SETR
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