About Vitamin K-dependent gamma-carboxylase
Vitamin K-dependent gamma-carboxylase (GGCX) is a protein
from Homo sapiens identified by UniProt accession
P38435, 758 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | Vitamin K-dependent gamma-carboxylase |
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| UniProt accession | P38435 |
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| Gene | GGCX |
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| Organism | Homo sapiens |
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| Length | 758 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (115)
Diseases linked to this target (Open Targets).
- body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency · score 0.74
- vitamin K-dependent clotting factors, combined deficiency of, type 1 · score 0.73
- Hereditary combined deficiency of vitamin K-dependent clotting factors · score 0.72
- reticulocyte count · score 0.27
- eosinophil count · score 0.26
- coronary artery disease · score 0.24
- prostate carcinoma · score 0.23
- angina pectoris · score 0.21
- myocardial infarction · score 0.21
- urinary albumin to creatinine ratio · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P38435-F1 | alphafold | PREDICTED | 86.02 | — |
Amino-acid sequence (758 residues)
MAVSAGSART SPSSDKVQKD KAELISGPRQ DSRIGKLLGF EWTDLSSWRR LVTLLNRPTD PASLAVFRFL FGFLMVLDIP QERGLSSLDR KYLDGLDVCR FPLLDALRPL PLDWMYLVYT IMFLGALGMM LGLCYRISCV LFLLPYWYVF LLDKTSWNNH SYLYGLLAFQ LTFMDANHYW SVDGLLNAHR RNAHVPLWNY AVLRGQIFIV YFIAGVKKLD ADWVEGYSME YLSRHWLFSP FKLLLSEELT SLLVVHWGGL LLDLSAGFLL FFDVSRSIGL FFVSYFHCMN SQLFSIGMFS YVMLASSPLF CSPEWPRKLV SYCPRRLQQL LPLKAAPQPS VSCVYKRSRG KSGQKPGLRH QLGAAFTLLY LLEQLFLPYS HFLTQGYNNW TNGLYGYSWD MMVHSRSHQH VKITYRDGRT GELGYLNPGV FTQSRRWKDH ADMLKQYATC LSRLLPKYNV TEPQIYFDIW VSINDRFQQR IFDPRVDIVQ AAWSPFQRTS WVQPLLMDLS PWRAKLQEIK SSLDNHTEVV FIADFPGLHL ENFVSEDLGN TSIQLLQGEV TVELVAEQKN QTLREGEKMQ LPAGEYHKVY TTSPSPSCYM YVYVNTTELA LEQDLAYLQE LKEKVENGSE TGPLPPELQP LLEGEVKGGP EPTPLVQTFL RRQQRLQEIE RRRNTPFHER FFRFLLRKLY VFRRSFLMTC ISLRNLILGR PSLEQLAQEV TYANLRPFEA VGELNPSNTD SSHSNPPESN PDPVHSEF
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