V-type proton ATPase catalytic subunit A (ATP6V1A)

About V-type proton ATPase catalytic subunit A

V-type proton ATPase catalytic subunit A (ATP6V1A) is a protein from Homo sapiens identified by UniProt accession P38606, 617 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	V-type proton ATPase catalytic subunit A
UniProt accession	P38606
Gene	ATP6V1A
Organism	Homo sapiens
Length	617 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

developmental and epileptic encephalopathy · score 0.67
neurodegenerative disease · score 0.57
autosomal recessive cutis laxa type 2, classic type · score 0.55
Alzheimer disease · score 0.50
lysosomal storage disease · score 0.50
Parkinson disease · score 0.50
multiple sclerosis · score 0.50
autosomal recessive cutis laxa type 2 · score 0.46
genetic disorder · score 0.37
undetermined early-onset epileptic encephalopathy · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P38606-F1	alphafold	PREDICTED	90.82	—

Amino-acid sequence (617 residues)

MDFSKLPKIL DEDKESTFGY VHGVSGPVVT ACDMAGAAMY ELVRVGHSEL VGEIIRLEGD MATIQVYEET SGVSVGDPVL RTGKPLSVEL GPGIMGAIFD GIQRPLSDIS SQTQSIYIPR GVNVSALSRD IKWDFTPCKN LRVGSHITGG DIYGIVSENS LIKHKIMLPP RNRGTVTYIA PPGNYDTSDV VLELEFEGVK EKFTMVQVWP VRQVRPVTEK LPANHPLLTG QRVLDALFPC VQGGTTAIPG AFGCGKTVIS QSLSKYSNSD VIIYVGCGER GNEMSEVLRD FPELTMEVDG KVESIMKRTA LVANTSNMPV AAREASIYTG ITLSEYFRDM GYHVSMMADS TSRWAEALRE ISGRLAEMPA DSGYPAYLGA RLASFYERAG RVKCLGNPER EGSVSIVGAV SPPGGDFSDP VTSATLGIVQ VFWGLDKKLA QRKHFPSVNW LISYSKYMRA LDEYYDKHFT EFVPLRTKAK EILQEEEDLA EIVQLVGKAS LAETDKITLE VAKLIKDDFL QQNGYTPYDR FCPFYKTVGM LSNMIAFYDM ARRAVETTAQ SDNKITWSII REHMGDILYK LSSMKFKDPL KDGEAKIKSD YAQLLEDMQN AFRSLED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards