About Stress-70 protein, mitochondrial
Stress-70 protein, mitochondrial (HSPA9) is a protein
from Homo sapiens identified by UniProt accession
P38646, 679 residues long.
MolForge cross-references it against 0 known binders and
258 disease associations.
Target properties
| Protein name | Stress-70 protein, mitochondrial |
|---|
| UniProt accession | P38646 |
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| Gene | HSPA9 |
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| Organism | Homo sapiens |
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| Length | 679 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (258)
Diseases linked to this target (Open Targets).
- even-plus syndrome · score 0.68
- autosomal dominant sideroblastic anemia · score 0.65
- Red cell distribution width · score 0.58
- mean corpuscular hemoglobin · score 0.58
- mean corpuscular volume · score 0.53
- Constitutional sideroblastic anemia · score 0.46
- autosomal recessive sideroblastic anemia · score 0.37
- Sideroblastic anemia · score 0.37
- mean corpuscular hemoglobin concentration · score 0.28
- neurodegenerative disease · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P38646-F1 | alphafold | PREDICTED | 85.96 | — |
Amino-acid sequence (679 residues)
MISASRAAAA RLVGAAASRG PTAARHQDSW NGLSHEAFRL VSRRDYASEA IKGAVVGIDL GTTNSCVAVM EGKQAKVLEN AEGARTTPSV VAFTADGERL VGMPAKRQAV TNPNNTFYAT KRLIGRRYDD PEVQKDIKNV PFKIVRASNG DAWVEAHGKL YSPSQIGAFV LMKMKETAEN YLGHTAKNAV ITVPAYFNDS QRQATKDAGQ ISGLNVLRVI NEPTAAALAY GLDKSEDKVI AVYDLGGGTF DISILEIQKG VFEVKSTNGD TFLGGEDFDQ ALLRHIVKEF KRETGVDLTK DNMALQRVRE AAEKAKCELS SSVQTDINLP YLTMDSSGPK HLNMKLTRAQ FEGIVTDLIR RTIAPCQKAM QDAEVSKSDI GEVILVGGMT RMPKVQQTVQ DLFGRAPSKA VNPDEAVAIG AAIQGGVLAG DVTDVLLLDV TPLSLGIETL GGVFTKLINR NTTIPTKKSQ VFSTAADGQT QVEIKVCQGE REMAGDNKLL GQFTLIGIPP APRGVPQIEV TFDIDANGIV HVSAKDKGTG REQQIVIQSS GGLSKDDIEN MVKNAEKYAE EDRRKKERVE AVNMAEGIIH DTETKMEEFK DQLPADECNK LKEEISKMRE LLARKDSETG ENIRQAASSL QQASLKLFEM AYKKMASERE GSGSSGTGEQ KEDQKEEKQ
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