Eukaryotic initiation factor 4A-III (EIF4A3)

About Eukaryotic initiation factor 4A-III

Eukaryotic initiation factor 4A-III (EIF4A3) is a protein from Homo sapiens identified by UniProt accession P38919, 411 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.

Target properties

Protein name	Eukaryotic initiation factor 4A-III
UniProt accession	P38919
Gene	EIF4A3
Organism	Homo sapiens
Length	411 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (106)

Diseases linked to this target (Open Targets).

Richieri Costa-Pereira syndrome · score 0.74
Intellectual disability · score 0.37
microtia · score 0.37
Cleft mandible · score 0.37
Talipes equinovarus · score 0.37
Cleft palate · score 0.37
clubfoot · score 0.37
Pierre-Robin sequence · score 0.37
Short stature · score 0.37
cleft palate · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P38919-F1	alphafold	PREDICTED	88.62	—

Amino-acid sequence (411 residues)

MATTATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL RGIYAYGFEK PSAIQQRAIK QIIKGRDVIA QSQSGTGKTA TFSISVLQCL DIQVRETQAL ILAPTRELAV QIQKGLLALG DYMNVQCHAC IGGTNVGEDI RKLDYGQHVV AGTPGRVFDM IRRRSLRTRA IKMLVLDEAD EMLNKGFKEQ IYDVYRYLPP ATQVVLISAT LPHEILEMTN KFMTDPIRIL VKRDELTLEG IKQFFVAVER EEWKFDTLCD LYDTLTITQA VIFCNTKRKV DWLTEKMREA NFTVSSMHGD MPQKERESIM KEFRSGASRV LISTDVWARG LDVPQVSLII NYDLPNNREL YIHRIGRSGR YGRKGVAINF VKNDDIRILR DIEQYYSTQI DEMPMNVADL I

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards