About DNA-binding protein SMUBP-2
DNA-binding protein SMUBP-2 (IGHMBP2) is a protein
from Homo sapiens identified by UniProt accession
P38935, 993 residues long.
MolForge cross-references it against 0 known binders and
381 disease associations.
Target properties
| Protein name | DNA-binding protein SMUBP-2 |
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| UniProt accession | P38935 |
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| Gene | IGHMBP2 |
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| Organism | Homo sapiens |
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| Length | 993 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (381)
Diseases linked to this target (Open Targets).
- autosomal recessive distal spinal muscular atrophy 1 · score 0.84
- Spinal muscular atrophy with respiratory distress type 1 · score 0.81
- Charcot-Marie-Tooth disease axonal type 2S · score 0.78
- genetic disorder · score 0.54
- neurodegenerative disease · score 0.52
- distal hereditary motor neuropathy · score 0.48
- Charcot-Marie-Tooth disease · score 0.48
- peripheral neuropathy · score 0.45
- spinal muscular atrophy · score 0.42
- Neurodevelopmental disorder · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P38935-F1 | alphafold | PREDICTED | 77.35 | — |
Amino-acid sequence (993 residues)
MASAAVESFV TKQLDLLELE RDAEVEERRS WQENISLKEL QSRGVCLLKL QVSSQRTGLY GRLLVTFEPR RYGSAAALPS NSFTSGDIVG LYDAANEGSQ LATGILTRVT QKSVTVAFDE SHDFQLSLDR ENSYRLLKLA NDVTYRRLKK ALIALKKYHS GPASSLIEVL FGRSAPSPAS EIHPLTFFNT CLDTSQKEAV LFALSQKELA IIHGPPGTGK TTTVVEIILQ AVKQGLKVLC CAPSNIAVDN LVERLALCKQ RILRLGHPAR LLESIQQHSL DAVLARSDSA QIVADIRKDI DQVFVKNKKT QDKREKSNFR NEIKLLRKEL KEREEAAMLE SLTSANVVLA TNTGASADGP LKLLPESYFD VVVIDECAQA LEASCWIPLL KARKCILAGD HKQLPPTTVS HKAALAGLSL SLMERLAEEY GARVVRTLTV QYRMHQAIMR WASDTMYLGQ LTAHSSVARH LLRDLPGVAA TEETGVPLLL VDTAGCGLFE LEEEDEQSKG NPGEVRLVSL HIQALVDAGV PARDIAVVSP YNLQVDLLRQ SLVHRHPELE IKSVDGFQGR EKEAVILSFV RSNRKGEVGF LAEDRRINVA VTRARRHVAV ICDSRTVNNH AFLKTLVEYF TQHGEVRTAF EYLDDIVPEN YSHENSQGSS HAATKPQGPA TSTRTGSQRQ EGGQEAAAPA RQGRKKPAGK SLASEAPSQP SLNGGSPEGV ESQDGVDHFR AMIVEFMASK KMQLEFPPSL NSHDRLRVHQ IAEEHGLRHD SSGEGKRRFI TVSKRAPRPR AALGPPAGTG GPAPLQPVPP TPAQTEQPPR EQRGPDQPDL RTLHLERLQR VRSAQGQPAS KEQQASGQQK LPEKKKKKAK GHPATDLPTE EDFEALVSAA VKADNTCGFA KCTAGVTTLG QFCQLCSRRY CLSHHLPEIH GCGERARAHA RQRISREGVL YAGSGTKNGS LDPAKRAQLQ RRLDKKLSEL SNQRTSRRKE RGT
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