About Cyclin-dependent kinase inhibitor 1
Cyclin-dependent kinase inhibitor 1 (CDKN1A) is a protein
from Homo sapiens identified by UniProt accession
P38936, 164 residues long.
MolForge cross-references it against 0 known binders and
660 disease associations.
Target properties
| Protein name | Cyclin-dependent kinase inhibitor 1 |
|---|
| UniProt accession | P38936 |
|---|
| Gene | CDKN1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 164 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (660)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.57
- urinary bladder cancer · score 0.53
- Parkinson disease · score 0.53
- multiple sclerosis · score 0.53
- lysosomal storage disease · score 0.53
- Alzheimer disease · score 0.53
- neuroinflammatory disorder · score 0.42
- urinary bladder carcinoma · score 0.41
- electrocardiography · score 0.40
- serum alanine aminotransferase measurement · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P38936-F1 | alphafold | PREDICTED | 69.00 | — |
Amino-acid sequence (164 residues)
MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP
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