Large ribosomal subunit protein uL3 (RPL3)

About Large ribosomal subunit protein uL3

Large ribosomal subunit protein uL3 (RPL3) is a protein from Homo sapiens identified by UniProt accession P39023, 403 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Large ribosomal subunit protein uL3
UniProt accession	P39023
Gene	RPL3
Organism	Homo sapiens
Length	403 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
Becker muscular dystrophy · score 0.29
clear cell renal carcinoma · score 0.27
endometrial cancer · score 0.27
qualitative or quantitative defects of dystrophin · score 0.26
ulcerative colitis · score 0.18
interstitial lung disease · score 0.18
inflammatory bowel disease · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P39023-F1	alphafold	PREDICTED	96.36	—

Amino-acid sequence (403 residues)

MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVVVGIV GYVETPRGLR TFKTVFAEHI SDECKRRFYK NWHKSKKKAF TKYCKKWQDE DGKKQLEKDF SSMKKYCQVI RVIAHTQMRL LPLRQKKAHL MEIQVNGGTV AEKLDWARER LEQQVPVNQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL PRKTHRGLRK VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK NNASTDYDLS DKSINPLGGF VHYGEVTNDF VMLKGCVVGT KKRVLTLRKS LLVQTKRRAL EKIDLKFIDT TSKFGHGRFQ TMEEKKAFMG PLKKDRIAKE EGA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards