Mitochondrial inner membrane protein Mpv17 (MPV17)

About Mitochondrial inner membrane protein Mpv17

Mitochondrial inner membrane protein Mpv17 (MPV17) is a protein from Homo sapiens identified by UniProt accession P39210, 176 residues long. MolForge cross-references it against 0 known binders and 154 disease associations.

Target properties

Protein name	Mitochondrial inner membrane protein Mpv17
UniProt accession	P39210
Gene	MPV17
Organism	Homo sapiens
Length	176 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (154)

Diseases linked to this target (Open Targets).

mitochondrial DNA depletion syndrome 6 (hepatocerebral type) · score 0.85
Charcot-Marie-Tooth disease, axonal, type 2EE · score 0.75
mitochondrial DNA depletion syndrome · score 0.65
mitochondrial DNA depletion syndrome 15 (hepatocerebral type) · score 0.48
liver failure · score 0.37
Cholestasis · score 0.37
mitochondrial disease · score 0.37
cholestasis · score 0.37
hereditary sensory and autonomic neuropathy type 4 · score 0.18
genetic disorder · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P39210-F1	alphafold	PREDICTED	90.38	—

Amino-acid sequence (176 residues)

MALWRAYQRA LAAHPWKVQV LTAGSLMGLG DIISQQLVER RGLQEHQRGR TLTMVSLGCG FVGPVVGGWY KVLDRFIPGT TKVDALKKML LDQGGFAPCF LGCFLPLVGA LNGLSAQDNW AKLQRDYPDA LITNYYLWPA VQLANFYLVP LHYRLAVVQC VAVIWNSYLS WKAHRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards