About Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST) is a protein
from Homo sapiens identified by UniProt accession
P39656, 456 residues long.
MolForge cross-references it against 0 known binders and
106 disease associations.
Target properties
| Protein name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit |
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| UniProt accession | P39656 |
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| Gene | DDOST |
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| Organism | Homo sapiens |
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| Length | 456 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (106)
Diseases linked to this target (Open Targets).
- DDOST-congenital disorder of glycosylation · score 0.67
- neurodegenerative disease · score 0.54
- lysosomal storage disease · score 0.37
- COVID-19 · score 0.37
- congenital disorder of glycosylation · score 0.19
- Intellectual disability · score 0.12
- leprosy · score 0.11
- endometrial cancer · score 0.11
- neoplasm · score 0.06
- hemoglobin D disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P39656-F1 | alphafold | PREDICTED | 89.16 | — |
Amino-acid sequence (456 residues)
MGYFRCARAG SFGRRRKMEP STAARAWALF WLLLPLLGAV CASGPRTLVL LDNLNVRETH SLFFRSLKDR GFELTFKTAD DPSLSLIKYG EFLYDNLIIF SPSVEDFGGN INVETISAFI DGGGSVLVAA SSDIGDPLRE LGSECGIEFD EEKTAVIDHH NYDISDLGQH TLIVADTENL LKAPTIVGKS SLNPILFRGV GMVADPDNPL VLDILTGSST SYSFFPDKPI TQYPHAVGKN TLLIAGLQAR NNARVIFSGS LDFFSDSFFN SAVQKAAPGS QRYSQTGNYE LAVALSRWVF KEEGVLRVGP VSHHRVGETA PPNAYTVTDL VEYSIVIQQL SNGKWVPFDG DDIQLEFVRI DPFVRTFLKK KGGKYSVQFK LPDVYGVFQF KVDYNRLGYT HLYSSTQVSV RPLQHTQYER FIPSAYPYYA SAFSMMLGLF IFSIVFLHMK EKEKSD
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