Phospholipase A2 group V (PLA2G5)

About Phospholipase A2 group V

Phospholipase A2 group V (PLA2G5) is a protein from Homo sapiens identified by UniProt accession P39877, 138 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.

Target properties

Protein name	Phospholipase A2 group V
UniProt accession	P39877
Gene	PLA2G5
Organism	Homo sapiens
Length	138 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (101)

Diseases linked to this target (Open Targets).

familial benign flecked retina · score 0.61
neurodegenerative disease · score 0.36
late-onset retinal degeneration · score 0.33
phospholipase A2, membrane associated measurement · score 0.27
acute coronary syndrome · score 0.15
cutaneous melanoma · score 0.10
coronary artery disease · score 0.10
acute lung injury · score 0.05
kidney disease · score 0.04
hemochromatosis type 2B · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P39877-F1	alphafold	PREDICTED	91.71	—

Amino-acid sequence (138 residues)

MKGLLPLAWF LACSVPAVQG GLLDLKSMIE KVTGKNALTN YGFYGCYCGW GGRGTPKDGT DWCCWAHDHC YGRLEEKGCN IRTQSYKYRF AWGVVTCEPG PFCHVNLCAC DRKLVYCLKR NLRSYNPQYQ YFPNILCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards