About Glial cell line-derived neurotrophic factor
Glial cell line-derived neurotrophic factor (GDNF) is a protein
from Homo sapiens identified by UniProt accession
P39905, 211 residues long.
MolForge cross-references it against 0 known binders and
628 disease associations.
Target properties
| Protein name | Glial cell line-derived neurotrophic factor |
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| UniProt accession | P39905 |
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| Gene | GDNF |
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| Organism | Homo sapiens |
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| Length | 211 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (628)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.35
- Hirschsprung disease · score 0.34
- prostate carcinoma · score 0.33
- glioblastoma multiforme · score 0.32
- blood protein measurement · score 0.30
- breast adenocarcinoma · score 0.29
- interleukin-8 measurement · score 0.27
- worry measurement · score 0.24
- diverticular disease · score 0.22
- adrenal gland pheochromocytoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P39905-F1 | alphafold | PREDICTED | 75.02 | — |
Amino-acid sequence (211 residues)
MKLWDVVAVC LVLLHTASAF PLPAGKRPPE APAEDRSLGR RRAPFALSSD SNMPEDYPDQ FDDVMDFIQA TIKRLKRSPD KQMAVLPRRE RNRQAAAANP ENSRGKGRRG QRGKNRGCVL TAIHLNVTDL GLGYETKEEL IFRYCSGSCD AAETTYDKIL KNLSRNRRLV SDKVGQACCR PIAFDDDLSF LDDNLVYHIL RKHSAKRCGC I
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