About Macrophage-capping protein
Macrophage-capping protein (CAPG) is a protein
from Homo sapiens identified by UniProt accession
P40121, 348 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Macrophage-capping protein |
|---|
| UniProt accession | P40121 |
|---|
| Gene | CAPG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 348 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (121)
Diseases linked to this target (Open Targets).
- platelet component distribution width · score 0.27
- mean platelet volume · score 0.27
- blood protein measurement · score 0.27
- platelet count · score 0.22
- adolescent idiopathic scoliosis · score 0.18
- urate measurement · score 0.17
- uric acid measurement · score 0.17
- lymphocyte percentage of leukocytes · score 0.09
- breast cancer · score 0.08
- nonpapillary renal cell carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P40121-F1 | alphafold | PREDICTED | 86.43 | — |
Amino-acid sequence (348 residues)
MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV LHNGPEEVSH LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGHESPIF KQFFKDWK
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