Adenylyl cyclase-associated protein 2 (CAP2)

About Adenylyl cyclase-associated protein 2

Adenylyl cyclase-associated protein 2 (CAP2) is a protein from Homo sapiens identified by UniProt accession P40123, 477 residues long. MolForge cross-references it against 0 known binders and 300 disease associations.

Target properties

Protein name	Adenylyl cyclase-associated protein 2
UniProt accession	P40123
Gene	CAP2
Organism	Homo sapiens
Length	477 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (300)

Diseases linked to this target (Open Targets).

cardiomyopathy, dilated, 2I · score 0.48
familial isolated dilated cardiomyopathy · score 0.38
testosterone measurement · score 0.38
hemorrhoid · score 0.36
cutaneous melanoma · score 0.13
hypertrophic cardiomyopathy · score 0.08
Romano-Ward syndrome · score 0.08
Brugada syndrome · score 0.07
dilated cardiomyopathy · score 0.07
familial atrial fibrillation · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40123-F1	alphafold	PREDICTED	82.82	—

Amino-acid sequence (477 residues)

MANMQGLVER LERAVSRLES LSAESHRPPG NCGEVNGVIA GVAPSVEAFD KLMDSMVAEF LKNSRILAGD VETHAEMVHS AFQAQRAFLL MASQYQQPHE NDVAALLKPI SEKIQEIQTF RERNRGSNMF NHLSAVSESI PALGWIAVSP KPGPYVKEMN DAATFYTNRV LKDYKHSDLR HVDWVKSYLN IWSELQAYIK EHHTTGLTWS KTGPVASTVS AFSVLSSGPG LPPPPPPLPP PGPPPLFENE GKKEESSPSR SALFAQLNQG EAITKGLRHV TDDQKTYKNP SLRAQGGQTQ SPTKSHTPSP TSPKSYPSQK HAPVLELEGK KWRVEYQEDR NDLVISETEL KQVAYIFKCE KSTIQIKGKV NSIIIDNCKK LGLVFDNVVG IVEVINSQDI QIQVMGRVPT ISINKTEGCH IYLSEDALDC EIVSAKSSEM NILIPQDGDY REFPIPEQFK TAWDGSKLIT EPAEIMA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards