L-dopachrome tautomerase (DCT)

About L-dopachrome tautomerase

L-dopachrome tautomerase (DCT) is a protein from Homo sapiens identified by UniProt accession P40126, 519 residues long. MolForge cross-references it against 0 known binders and 186 disease associations.

Target properties

Protein name	L-dopachrome tautomerase
UniProt accession	P40126
Gene	DCT
Organism	Homo sapiens
Length	519 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (186)

Diseases linked to this target (Open Targets).

oculocutaneous albinism type 8 · score 0.67
albinism · score 0.36
skin pigmentation · score 0.35
Familial adenomatous polyposis · score 0.34
classic familial adenomatous polyposis · score 0.34
hair color · score 0.34
age related macular degeneration 7 · score 0.33
hair colour measurement · score 0.33
kidney disease · score 0.32
suntan · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40126-F1	alphafold	PREDICTED	89.10	—

Amino-acid sequence (519 residues)

MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN VCGSQQGRGQ CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN FAGYNCGDCK FGWTGPNCER KKPPVIRQNI HSLSPQEREQ FLGALDLAKK RVHPDYVITT QHWLGLLGPN GTQPQFANCS VYDFFVWLHY YSVRDTLLGP GRPYRAIDFS HQGPAFVTWH RYHLLCLERD LQRLIGNESF ALPYWNFATG RNECDVCTDQ LFGAARPDDP TLISRNSRFS SWETVCDSLD DYNHLVTLCN GTYEGLLRRN QMGRNSMKLP TLKDIRDCLS LQKFDNPPFF QNSTFSFRNA LEGFDKADGT LDSQVMSLHN LVHSFLNGTN ALPHSAANDP IFVVLHSFTD AIFDEWMKRF NPPADAWPQE LAPIGHNRMY NMVPFFPPVT NEELFLTSDQ LGYSYAIDLP VSVEETPGWP TTLLVVMGTL VALVGLFVLL AFLQYRRLRK GYTPLMETHL SSKRYTEEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards