About Platelet glycoprotein V
Platelet glycoprotein V (GP5) is a protein
from Homo sapiens identified by UniProt accession
P40197, 560 residues long.
MolForge cross-references it against 0 known binders and
144 disease associations.
Target properties
| Protein name | Platelet glycoprotein V |
|---|
| UniProt accession | P40197 |
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| Gene | GP5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 560 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (144)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.38
- platelet component distribution width · score 0.36
- platelet count · score 0.35
- lung adenocarcinoma · score 0.23
- cutaneous melanoma · score 0.20
- squamous cell lung carcinoma · score 0.19
- endometrial cancer · score 0.18
- basophil count · score 0.16
- erythrocyte count · score 0.15
- head and neck squamous cell carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P40197-F1 | alphafold | PREDICTED | 86.47 | — |
Amino-acid sequence (560 residues)
MLRGTLLCAV LGLLRAQPFP CPPACKCVFR DAAQCSGGDV ARISALGLPT NLTHILLFGM GRGVLQSQSF SGMTVLQRLM ISDSHISAVA PGTFSDLIKL KTLRLSRNKI THLPGALLDK MVLLEQLFLD HNALRGIDQN MFQKLVNLQE LALNQNQLDF LPASLFTNLE NLKLLDLSGN NLTHLPKGLL GAQAKLERLL LHSNRLVSLD SGLLNSLGAL TELQFHRNHI RSIAPGAFDR LPNLSSLTLS RNHLAFLPSA LFLHSHNLTL LTLFENPLAE LPGVLFGEMG GLQELWLNRT QLRTLPAAAF RNLSRLRYLG VTLSPRLSAL PQGAFQGLGE LQVLALHSNG LTALPDGLLR GLGKLRQVSL RRNRLRALPR ALFRNLSSLE SVQLDHNQLE TLPGDVFGAL PRLTEVLLGH NSWRCDCGLG PFLGWLRQHL GLVGGEEPPR CAGPGAHAGL PLWALPGGDA ECPGPRGPPP RPAADSSSEA PVHPALAPNS SEPWVWAQPV TTGKGQDHSP FWGFYFLLLA VQAMITVIIV FAMIKIGQLF RKLIRERALG
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