Alpha-taxilin (TXLNA)

About Alpha-taxilin

Alpha-taxilin (TXLNA) is a protein from Homo sapiens identified by UniProt accession P40222, 546 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	Alpha-taxilin
UniProt accession	P40222
Gene	TXLNA
Organism	Homo sapiens
Length	546 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

lean body mass · score 0.21
anthropometric measurement · score 0.16
base metabolic rate measurement · score 0.16
whole body water mass · score 0.16
body height · score 0.15
body weights and measures · score 0.13
pancreatic adenocarcinoma · score 0.07
hemoglobin D disease · score 0.05
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.05
delta-beta-thalassemia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P40222-F1	alphafold	PREDICTED	73.60	—

Amino-acid sequence (546 residues)

MKNQDKKNGA AKQSNPKSSP GQPEAGPEGA QERPSQAAPA VEAEGPGSSQ APRKPEGAQA RTAQSGALRD VSEELSRQLE DILSTYCVDN NQGGPGEDGA QGEPAEPEDA EKSRTYVARN GEPEPTPVVN GEKEPSKGDP NTEEIRQSDE VGDRDHRRPQ EKKKAKGLGK EITLLMQTLN TLSTPEEKLA ALCKKYAELL EEHRNSQKQM KLLQKKQSQL VQEKDHLRGE HSKAVLARSK LESLCRELQR HNRSLKEEGV QRAREEEEKR KEVTSHFQVT LNDIQLQMEQ HNERNSKLRQ ENMELAERLK KLIEQYELRE EHIDKVFKHK DLQQQLVDAK LQQAQEMLKE AEERHQREKD FLLKEAVESQ RMCELMKQQE THLKQQLALY TEKFEEFQNT LSKSSEVFTT FKQEMEKMTK KIKKLEKETT MYRSRWESSN KALLEMAEEK TVRDKELEGL QVKIQRLEKL CRALQTERND LNKRVQDLSA GGQGSLTDSG PERRPEGPGA QAPSSPRVTE APCYPGAPST EASGQTGPQE PTSARA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards